The aim of the present investigation is to prepare and evaluate in-situ gel forming ophthalmic drug delivery system of ciprofloxacin hydrochloride. Sodium alginate, a novel ophthalmic gel-forming mucoadhesive polymer, which gets converted to gel in the presence of divalent-cations (calcium ion) present in the lachrymal fluid, was used as the gelling agents. Hydroxyl propyl methyl cellulose (HPMC) is a mucoadhesive polymer used as viscosity enhancer. Suitable concentrations of buffering agents were used to adjust the pH to 6.5. All the formulations were sterilized in an autoclave. The formulation was evaluated for clarity, pH measurement, gelling capacity, drug content estimation, rheological study. Different concentration of HPMC and sodium alginate were tailored and their effects were observed. The result of evaluation parameters i.e. preformulations, viscosity and pH, showed satisfactory results.
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